(10681 Reviews)

The Home Kit

The Home Kit

A digestive enzyme blend that breaks down the most common FODMAP triggers.* Enjoy garlic, onion, bread, beans, and dairy without the aftermath.

$55.00
$55.00 $65.00
SAVE 15% Sold out

BUNDLE & SAVE

The Home Kit

The Home Kit

$55.00
$55.00 $65.00
SAVE 15% Sold out

Why a powder

Enzyme supplements work by making direct contact with food in the stomach. Capsules dissolve separately, limiting how much enzyme reaches FODMAPs before they ferment in the small intestine and cause symptoms. FODZYME®'s powder format ensures enzymes are pre-mixed with food, maximizing contact time.

In a peer-reviewed study (Castro Ochoa et al., Gastro Hep Advances, 2023), this approach degraded up to 90% of fructans within 30 minutes. A 2026 clinical study (Kaye et al., Gastro Hep Advances) found 78% of participants reported improvement in bloating from FODMAP ingestion after 4 weeks. FODZYME® is the only FODMAP enzyme supplement certified low-FODMAP by both Monash University and FODMAP Friendly.

How to use

Step 1

Allow hot foods to cool slightly before applying (below 140 °F / 60 °C).

Step 2

Mix directly or apply evenly on meals. It’s tasteless.

Step 3

Can’t mix? Sprinkle and chew with first bite.

Step 4

Double dose if extra sensitive or for large meals.

Ingredients

Fructan Hydrolase: One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.

Alpha-galactosidase: Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.

Lactase: Simplifies the digestion of lactose, commonly found in dairy products.

Dextrin: Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.

Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.

Dosage

FODZYME comes in two serving formats with the exact same enzyme blend in each. The Home Kit provides 0.75g per serving, which is our standard serving for meals at home where you typically have more visibility into ingredients. The On-the-Go Kit provides 1g per serving—a larger serving of the same product to help cover the hidden FODMAPs that are more common in restaurant meals. The Anywhere Bundle includes both the Home Kit and the On-the-Go Kit.

Serving size is not based on body weight or age. Instead, it depends on the size of the meal and its FODMAP content. Our servings are designed to work well for most customers and are based on the average amount of FODMAPs in meals and typical tolerance levels.

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 How It Works 

  • Step 1

    Allow hot foods to cool slightly before applying (below 140 °F / 60 °C).

  • Step 2

    Mix directly or apply evenly on meals. It’s tasteless.

  • Step 3

    Can’t mix? Sprinkle and chew with first bite.

  • Step 4

    Double dose if extra sensitive or for large meals.

     Why MembersLove FODZYME® 

    • "It took a few but Fodzyme was able to restore my gut’s balance so that I don’t need Miralax to have regularity."

       Chari 

    • "FODZYME makes my life more normal again. I don’t avoid and/or dread eating out anymore. I can travel with less stress."

       Brooke H. 

    • "It has changed my life! I can eat foods I have eaten in years! It really works!"

       Denise H. 

    • "So helpful to take the stress out. Now I don't bloat and I don't have discomfort after eating. And meals are blissfully not stressful!"

       Madeline H. 

       Meals Made Painless 

       Evidence & Research 

      • 90%

        Of fructan mass degraded within 30 minutes in a peer-reviewed simulated gastrointestinal study (Castro Ochoa et al., Gastro Hep Advances, 2023).1

      • 78%

        Reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks (Kaye et al., Gastro Hep Advances, 2026; P<.01).2

      • 73%

        Reported improvement in constipation from FODMAP ingestion after 4 weeks (Kaye et al., Gastro Hep Advances, 2026; P<.01).2

         Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) 

        FODZYME® is supported by two peer-reviewed publications in Gastro Hep Advances. In a SHIME® study (Castro Ochoa et al., 2023), it degraded 90% of fructans within 30 minutes while preserving short-chain fatty acid (SCFA) and butyrate production — unlike a strict low-FODMAP diet, which depletes SCFAs critical for colonic microbiome health. In an IRB-approved clinical cohort study independently analyzed at SUNY Downstate (Kaye et al., 2026), 78% of participants reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks, with significant improvements in quality of life and mental well-being (all P<.01).

         Feel The Difference With Your First Meal 

        Mix directly or apply evenly on meals.
        Double dosage when feasting. Chew well. Enjoy.

         Unlock New Foods 

        Our current formula effectively breaks down the FODMAPs fructan (e.g., garlic, onion, wheat, ...), GOS (e.g., legumes, nuts), and lactose (e.g., dairy products). We are actively developing a solution for polyols (e.g., apple, avocado, mushrooms) such as sorbitol and mannitol.

        Our current formula effectively breaks down the FODMAPs fructan (e.g., garlic, onion, wheat, ...), GOS (e.g., legumes, nuts), and lactose (e.g., dairy products). We are actively developing a solution for polyols (e.g., apple, avocado, mushrooms) such as sorbitol and mannitol.

         Tasteless Formulation 

         ACTIVE INGREDIENTS: 

        Our fructan hydrolase is the first ever enzyme to target fructans like inulin, fructo-oligosaccharides (FOS), and levan.

        Our alpha-galactosidase enzyme breaks down the galacto-oligosaccharides (GOS) or galactans (“O” in FODMAPs).

        Our lactase enzyme (also called β-D-galactosidase) can break down lactose (the “D” in FODMAPs).

        FODZYME® is formulated as a tasteless powder to ensure maximum contact between its digestive enzymes and FODMAP-containing foods, allowing for more effective breakdown of FODMAPs during digestion. Unlike capsules, the powder mixes directly with food, optimizing enzyme performance and supporting better digestive relief.

        Our formulation consists of clinically and scientifically studied microbial enzymes characterized at both academic institutions, and research partners.

        Non-GMO

        Soy-free

        Nut-free

        Kosher

        Gluten Free

        Dairy-free

        Casein-free

        No artificial flavors

        Vegan

        Egg-free

        Wheat-free

        FDA-Registered Facility

         Hi 👋, We’reCo-FoundersAnjie and David! 

        Anjie Liu

        Anjie created FODZYME® after battling IBS and the limitations of a low-FODMAP diet. A Harvard-trained physicist and Forbes 30 Under 30 honoree, she leads with a personal mission: to help people enjoy food without fear.

        David Hachuel, MPH

        David brings deep experience in gut health technology, including founding auggi.ai (acquired by Seed Health). With degrees from Harvard, NYU, and Cornell, he drives FODZYME®’s science, product, and growth to make digestive freedom a reality.

         Our Scientific Advisory Board Includes Experts In Gastroenterology, Biotechnology, Computational Biology, And Nutrition, Representing World-Class Institutions. 

        • William D. Chey, MD

          Advisor, Professor of Gastroenterology at the University of Michigan and Board member at the American College of Gastroenterology (ACG) and Rome Foundation

        • Shalaka Samant, PhD

          Founding Scientist at Kiwi Biosciences, former postdoctoral researcher at the Yale University School of Medicine

        • Thomas Wallach, MD

          Advisor, Assistant Professor at SUNY Downstate Medical Center, Pediatric Gastroenterology

        • Jocelyn Wells, MS, RDN

          A dietitian with a Master's in Clinical Nutrition, Jocelyn leads FODZYME®'s healthcare partnerships. She bridges the latest research in digestive health and nutrition guidelines to help clinicians bring digestive relief to patients navigating IBS and FODMAPs.

           Frequently Asked Questions 

          What exactly is FODZYME®?

          Founded by an IBS sufferer, FODZYME® is a tasteless enzyme powder that breaks down FODMAPs — fermentable carbohydrates that trigger bloating, gas, diarrhea, constipation, and abdominal pain. It contains three active enzymes: fructan hydrolase (the first commercially available enzyme targeting fructans in garlic, onion, and wheat), alpha-galactosidase (for GOS in beans and legumes), and lactase (for lactose in dairy). FODZYME® is mixed directly with food before eating, manufactured in the USA, and independently certified low-FODMAP by Monash University

          What ingredients does FODZYME® contain?

          • Fructan Hydrolase: One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.
          • Alpha-galactosidase: Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.
          • Lactase: Simplifies the digestion of lactose, commonly found in dairy products.
          • Dextrin: Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.

          Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.

          Is FODZYME® allergen-friendly?

          Yes, FODZYME® is:

          • Certified low FODMAP by Monash University and FODMAP Friendly
          • Vegan-friendly
          • Non-GMO
          • Gluten-free
          • Dairy-free
          • Soy-free
          • Egg-free
          • Casein-free
          • Free from artificial colors and flavors
          • Manufactured in the USA with global ingredients
          • Certified Kosher by Kosher Supervision of America (KSA)

          What foods does FODZYME® help digest?

          FODZYME® targets three primary FODMAP groups—fructans, galacto-oligosaccharides (GOS), and lactose—which are common triggers for digestive discomfort. Its enzyme blend works on foods like garlic, onions, wheat, beans, lentils, dairy products, and certain vegetables, breaking these FODMAPs into easily digestible sugars.

          Key Food Groups Supported and Example Foods:

          • Fructans:Garlic, onions, leeks, wheat, barley, asparagus, artichokes, Brussels sprouts, and cashews.
          • GOS:Chickpeas, lentils, black beans, red kidney beans, soy milk (whole bean), pistachios, and oats.
          • Lactose:Milk, yogurt, ice cream, soft cheeses (ricotta, cottage cheese), and cream.

          How do I take FODZYME®?

          1. Mix Directly:Mix FODZYME® directly or apply evenly on meals. It’s tasteless.
          2. Alternate Method:If you can’t mix, sprinkle FODZYME® and chew with the first bite.
          3. Adjust Dosage:Dosage is personal—double the dose if extra sensitive or for large meals.
          4. Temperature Note:Allow hot foods to cool slightly before applying (below 140 °F / 60 °C). As a rule of thumb, adding FODZYME® is okay if the meal is cool enough that it won’t burn.
          5. Enjoy:Chew well and enjoy your meal!

          How is FODZYME® different from other digestive enzymes?

          Most digestive enzyme supplements contain proteases, lipases, and amylases that target proteins, fats, and starches — not FODMAPs, which are the primary dietary triggers of digestive symptoms like bloating, gas, and pain. FODZYME® is the first enzyme supplement specifically formulated to break down FODMAPs. Its proprietary fructan hydrolase targets fructans found in garlic, onion, and wheat, while alpha-galactosidase targets GOS in beans and legumes, and lactase targets lactose in dairy.

          FODZYME® is a powder rather than a capsule, ensuring direct enzyme-food contact during digestion. In a peer-reviewed study, this approach degraded up to 90% of fructans within 30 minutes (Castro Ochoa et al., Gastro Hep Advances, 2023). A 2026 clinical cohort study found 78% of participants reported improvement in bloating from FODMAP ingestion after 4 weeks (Kaye et al., Gastro Hep Advances, 2026; P<.01). It is the only enzyme supplement certified low-FODMAP by both Monash University and FODMAP Friendly.

          How quickly does FODZYME® work? When will I feel something?

          FODZYME® begins breaking down FODMAPs immediately upon contact with food. In a peer-reviewed study (Castro Ochoa et al., Gastro Hep Advances, 2023), it degraded up to 90% of fructans within 30 minutes under simulated gastric conditions. This rapid action breaks down FODMAPs in the stomach and upper small intestine — before they reach the colon where bacterial fermentation causes bloating and gas.

          Most users notice the absence of their usual symptoms 4–8 hours after a FODMAP-rich meal, consistent with normal gastrointestinal transit time. In an IRB-approved clinical study (Kaye et al., Gastro Hep Advances, 2026), 78% of participants reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks (P<.01).

          Can I use FODZYME® every day?

          Can I use FODZYME® every day?

          Will FODZYME® interfere with my medications?

          FODZYME® is generally considered safe to use alongside most medications, as its enzymes work specifically on FODMAPs in the digestive tract. However, it’s always a good idea to consult your healthcare provider or pharmacist before starting any new supplement—especially if you’re taking prescription medications.

          Individual responses can vary. If you notice any unusual symptoms or changes in medication effectiveness, discontinue use and consult your healthcare provider immediately.

          Is FODZYME® a cure for conditions like Irritable Bowel Syndrome (IBS)?

          No. FODZYME® is a digestive enzyme supplement, not a cure for Irritable Bowel Syndrome (IBS) or any medical condition. It works by breaking down specific FODMAP carbohydrates in food during digestion, which may reduce symptoms triggered by those foods — including bloating, gas, and abdominal pain. FODZYME® does not address the underlying causes of IBS.

          If you have been diagnosed with IBS or suspect you have a digestive disorder, consult a gastroenterologist or registered dietitian. FODZYME® can be used alongside medical treatment and the low-FODMAP diet as directed by your healthcare provider.

          Why is FODZYME® a powder instead of a capsule?

          FODZYME®’s powdered format mixes directly with your food for instant action on FODMAPs—no waiting for a capsule to dissolve. This allows for:

          • More immediate breakdown of problematic carbs.
          • Flexible dosing based on your meal’s FODMAP content.
          • Even distribution for better overall effectiveness in reducing digestive discomfort.

          Is FODZYME® safe to take while I'm pregnant or breastfeeding?

          FODZYME®’s enzymes work on your food without entering your body, making it a low-risk option. However, because studies on pregnant or breastfeeding women are limited for ethical reasons, there’s no concrete evidence it’s unsafe—but it’s best to consult your physician before use.

          Keep in mind that a low FODMAP diet isn’t generally advised during pregnancy due to potential nutritional restrictions, so always prioritize a nutrient-rich diet. Rest assured that all ingredients are GRAS-certified and undergo rigorous third-party testing for safety and quality

          What does my subscription to FODZYME® include?

          A FODZYME® subscription provides flexibility and savings by offering:

          • Home Kit:A 60-dose jar for everyday use.
          • On-the-Go Kit:30 single-serve packets for portability.

          You also have the option to subscribe to both. Subscribers receive a $15 discount on all orders, along with the ability to adjust delivery frequency, skip shipments, or cancel anytime.

          Do you ship internationally?

          Yes! We ship to the following countries:

          • United States
          • Australia
          • New Zealand
          • United Kingdom
          • Canada
          • Belgium
          • Netherlands
          • Poland
          • Austria
          • Germany
          • Czechia
          • Slovakia
          • Switzerland
          • United Arab Emirates
          • Israel
          • France
          • Denmark
          • Italy
          • Finland
          • Norway
          • Sweden